What’s the best way to handle medicinal plants grinding in a colloid mill without losing active compounds to excess heat?

For medicinal plants grinding, using a moderate gap setting combined with a cooling jacket around the mill housing helps limit temperature rise during high-shear processing, which protects heat-sensitive active compounds from degradation. Pre-drying and lightly pre-crushing the plant material before it enters the colloid mill also reduces residence time in the shear zone, resulting in a finer, more consistent particle size for downstream extraction or formulation.